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Clinical Fellowship Genetics, Cancer, Cytogenetics

I know the feeling that the words “incurable cancer” carry with them. My mother died of cancer, and, not long after this event, my father was also found to be a sufferer. My father survives, but these experiences confirmed me in my interest in genetics and have led me to a specific and passionate interest in cancer genetics so that fewer and fewer children will hear the dread words that I heard of my mother’s condition.

 I originally became interested in genetics during my medical school rotations. I excelled in pediatrics, clinical genetics ward, and pathology labs. I became fascinated by the genetic variations that played a role in the susceptibility to disease and wanted to pursue research in this area of work. Following my mother’s death, I determined to study the significance of genomic alteration to malignancies for application to diagnostic, prognostic, and predictive testing. During my career, I have been privileged to have practiced as a physician and to have been a researcher, and lecturer. Still, I have firmly concluded that I can make my most significant contribution in the area of diagnosis. My ultimate goal is to become the director of a genetics lab and a professor in a prestigious university. I firmly believe that I shall achieve these goals.

 After medical school, I was fortunate to be able to take up a post-doctoral fellowship in nephrology at one of the busiest and largest US hospitals. During this time, I noticed that ADPKD tissue exhibit a high frequency of anomalies on many chromosomal segments supporting the concept of molecular cytogenetic aberrations. I also became familiar with PKD, Alport Syndrome, Von Hippel Lindau Disease, Fabry, and other inherited diseases. To acquire further insight into the interaction of genetics and the environment, I joined a Master’s in Public Health program at XXXX University. This program gave me an understanding of the basics of current molecular genetics. During my research project, my Mentor and I hypothesized the concept of environmental cues on cancer through epigenetic factors. Our research was given an international award. I also had the opportunity to work under some very distinguished scientists, such as Professor XXXX, during ‘hands-on’ training on mice transgenesis. I acquired skills in transgenic technologies, RNA-mediated inheritance, DNA pronuclear microinjection, genotyping, and DNA extraction from ES cells. I also joined several genetics laboratories to practice molecular and cytogenetic techniques such as FISH and Microarray. In addition to co-authoring a paper on DMGK, through short-term training in pathology, at the University of Massachusetts, I am developing my skills in molecular techniques such as PCR, electrophoresis, and DNA-based phylogenetic studies.

 I am aware of the importance of cultural sensitivity in medicine. I have traveled widely when presenting my research, including visiting Germany, Turkey, Iran, Mexico, and Ecuador. Since arriving in the US, I have happily worked, studied, and socialized with people of many cultural and social backgrounds.

 I love challenges and solving problems; I seek to achieve something significant and valuable; I am endlessly curious about my areas of interest, and I am constantly striving to extend my knowledge of them; I am persistent and focused; I like to work with others in a team, but I am equally happy to concentrate on a problem on my own; and finally, I am passionate about genetics research. These characteristics have been proven in my highly successful study to date. I now seek to undertake research in the areas of clinical laboratory genetic-tumor cytogenetics as well as novel molecular diagnostics assays and monitoring their impact on patient care and prognosis.

 I am confident that this fellowship will enable me to make a significant contribution to current knowledge in my areas of interest and I eagerly look forward to doing so.

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